Sinclair Method Studies
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.

Naltrexone is a prescription-only medication approved to help treat alcohol dependence in Ireland. It works by blocking the brain’s opioid receptors, reducing the sense of pleasure from alcohol. This dampens the reward cycle and gradually lessens alcohol cravings.

That’s where The Sinclair Method (TSM) shines. This innovative approach offers an alternative: gradual reduction, using the medication naltrexone to change your brain’s response to alcohol, one drink at a time.

At Rethink Drink, we're proud to be leading the charge in reshaping how the UK approaches alcohol recovery. For too long, individuals seeking change have faced limited choices: abstinence-only programmes, rigid systems, and shame-based narratives. We exist to offer a smarter, science-backed alternative — The Sinclair Method (TSM).
